Recombinant Mouse IL-12 p40/IL-12B Protein (His Tag)

Specifications

Catalog number

PKSM041069-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.

Abbreviation

IL-12 p40; IL-12B

Synonyms

NKSF; IL-12/IL-23 p; IL-12 subunit p; NK cell stimulatory factor chain; NK cell Stimulating Factor Chain; CLMF; CLMF p; IL12 p; CLMF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40) ; IL12; IL-12 p40; IL12 p70; IL-12 p70; IL-12/IL-23 p40; NK cell Stimulating Factor Chain 2; p40; IL-12B; NKSF2; Interleukin-12 subunit beta; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; IL 12B; Il12b

UniProt

P43432

Accession Number

P43432

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met23-Ser335

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

36.8 kDa

Observed Molecular Weight

42-55 kDa

Species

Mouse