Recombinant Mouse Interleukin-16/IL-16 Protein (His Tag)

Specifications

Catalog number

PKSM041075-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse interleukin-16 (IL-16) is a single chain non-glycosylated polypeptide. IL-16 is widely expressed in human tissues including spleen, thymus, lymph nodes, peripheral leukocytes, bone marrow and cerebellum. IL-16 plays an important role instimulating a migratory response in CD4+ lymphocytes, monocytes, and eosinophils, inducing T-lymphocyte expression of interleukin 2 receptor.It was originally identified as a CD8+ T cell-derived chemoattractant for CD4+ cells. In addition to its chemotactic properties, IL-16 has also been shown to suppress HIV-1 replication in vitro and appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. It may act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Abbreviation

Interleukin-16; IL-16

Synonyms

NIL; Interleukin; Pro-interleukin; Interleukin-16; LCF; Lymphocyte chemoattractant factor; NIL16; PRIL16; prIL-16; Pro-interleukin-16; Il16

UniProt

O54824

Accession Number

O54824

Expression System

E.coli

Tag

N-His

Sequence

Ser1205-Ser1322

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

14.5 kDa

Observed Molecular Weight

14-16 kDa

Species

Mouse