Recombinant Mouse Interleukin-22/IL-22 Protein (mFc Tag)

Specifications

Catalog number

PKSM041084-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79% and 22% sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.

Abbreviation

Interleukin-22; IL-22

Synonyms

Interleukin; Cytokine Zcyto; IL-D; TIFIL; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-22a; IL-D110; IL-TIF; Interleukin-22a; TIFa; TIFIL-23; UNQ3099/PRO10096; zcyto18; Interleukin-22; T-cell-derived-inducible; factor (IL-TIF) ; Interleukin-22a (IL-22a) ; IL-TIF alpha; IL-10-related; IL-22; Il22a; Iltif; Iltifa; Il22; TIFa

UniProt

Q9JJY9

Accession Number

Q9JJY9

Expression System

HEK293 Cells

Tag

C-mFc

Sequence

Leu34-Val179

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

43.8 kDa

Observed Molecular Weight

50-65 kDa

Species

Mouse