Recombinant Mouse CD300a/LMIR1 Protein (Fc Tag)

Specifications

Catalog number

PKSM041101-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs) . When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type.

Abbreviation

CD300a; LMIR1

Synonyms

CD300 antigen-like family member A; CD300a; CD300a antigen; CD300a molecule; CLM8; CMRF-35H; CMRF35-like molecule 8; CMRF35H9; IRp60; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor; leukocyte immunoglobulin-like receptor

UniProt

Q6SJQ0

Accession Number

Q6SJQ0

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Leu28-Arg183

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

44.3 kDa

Observed Molecular Weight

58-75 kDa

Species

Mouse