Recombinant Mouse MBL2/MBP-C Protein

Specifications

Catalog number

PKSM041108-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mannose-binding Lectin (MBL) is an acute phase protein bearing to the family of collectins produced by the liver as a monomer that forms a triple helix. Once released in serum, it further polymerizes forming dimers to octamers. The degree of serum polymerization is critical for the biological activity of MBL. MBL has higher affinity to microbial polysaccharides or their glycoconjugates. MBL was shown earlier to bind cell surfaces of bacteria, fungi, protozoa and viruses and acts as an acute-phase plasma protein (APP) during infection and inflammation. MBL activates the lectin-complement pathway, promotes opsonophagocytosis and modulates inflammation.

Abbreviation

MBL2; MBP-C

Synonyms

MBL-2; Mannose Binding Lectin 2; Mannose binding lectin (C) ; Mannose-binding protein C; Mbl2; isoform CRA_b

UniProt

Q3UEK1

Accession Number

Q3UEK1

Expression System

HEK293 Cells

Tag

None

Sequence

Glu19-Asp244

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

24.0 kDa

Observed Molecular Weight

28 kDa

Species

Mouse