Recombinant Mouse NCR1 Protein (His Tag)

Specifications

Catalog number

PKSM041113-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Natural cytotoxicity triggering receptor 1 (NKp46/NCR1) is a single-pass type I membrane protein. It consists of two extracellular Ig-like domains followed by a short stalk region, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmictail. NKp46 is predominantly expressed in the embryo. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor celllines.

Abbreviation

NCR1

Synonyms

Activating receptor1; Lymphocyte antigen94; NK-p46; NKp46; Naturalkiller cell p46-related protein; mAR-1; mNKp46

UniProt

Q8C567

Accession Number

Q8C567

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu22-Asn255

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

53.5 kDa

Observed Molecular Weight

76 kDa

Species

Mouse