Recombinant Mouse NgR/RTN4R Protein (Fc Tag)

Specifications

Catalog number

PKSM041118-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Nogo Receptor (NgR) is a glycosylphosphoinositol (GPI) -anchored protein that belongs to the Nogo recptor family. Human NgR is predominantly expressed in neurons and their axons in the central nervous systems. As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG) and myelin oligodendrocyte glycoprotein (OMG), NgR mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. NgR may be proposed as a potential drug target for treatment of various neurological conditions. Additionally, NgR may play a role in regulating the function of gap junctions.

Abbreviation

NgR; RTN4R

Synonyms

NOGOR; NgR; Nogo Receptor; Nogo-66 Receptor; RTN4R; Reticulon-4 Receptor

UniProt

Q99PI8

Accession Number

Q99PI8

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Cys27-Ser447

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

72.7 kDa

Observed Molecular Weight

100-120 kDa

Species

Mouse