Recombinant Mouse TNFSF4/OX40L Protein (His Tag)

Specifications

Catalog number

PKSM041119-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

OX40 ligand (OX40L), also called CD252, is a single-pass type II membrane protein of the TNF/TNF receptor superfamily. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. OX40L–OX40 co-stimulation leads to activation of TNF receptor associated factor (TRAF) 2, 3 and 5. This pathway has been shown to prolong the survival of effector CD4+Th cells as well as contributes to generation of memory T cells.

Abbreviation

TNFSF4; OX40L

Synonyms

CD252; OX40 ligand; OX40L; Tnfsf4; Tumor necrosis factor ligand superfamily member 4

UniProt

P43488

Accession Number

P43488

Expression System

HEK293 Cells

Tag

N-His

Sequence

Ser51-Leu198

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

17.7 kDa

Observed Molecular Weight

20-23 kDa

Species

Mouse