Recombinant Mouse PDGFRa/CD140a Protein (Fc Tag)

Specifications

Catalog number

PKSM041120-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD) . The four PDGFs are inactive in their monomeric forms. PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-α and -β. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -αα, -ββ and -αβ. PDGFRα and PDGFRβ are members of the class III RTK family. Inappropriate PDGFRα and PDGFRβ signaling has been linked to a number of proliferative disorders.

Abbreviation

PDGFRa; CD140a

Synonyms

Alpha platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a; PDGF-R-alpha; PDGFR-alpha; PDGFRA; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor alpha

UniProt

P26618

Accession Number

P26618

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Leu25-Glu524

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

83.2 kDa

Observed Molecular Weight

120-150 kDa

Species

Mouse