Recombinant Mouse B7-H5/Gi24/VSIR Protein (His Tag)

Specifications

Catalog number

PKSM041125-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. VSIR is broadly expressed in the spleen, bone marrow, and other tissues. Diseases associated with VSIR include Ichthyosis, Congenital, Autosomal Recessive 6, and Monckeberg Arteriosclerosis. An important paralog of this gene is VSIG8.

Abbreviation

B7-H5; Gi24; VSIR

Synonyms

B7-H5; Dies1; GI24; PD-1H; Platelet receptor Gi24; SISP1; VISTA; stress induced secreted protein 1

UniProt

Q9D659

Accession Number

Q9D659

Expression System

HEK293 Cells

Tag

C-His

Sequence

Phe33-Ala191

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.6 kDa

Observed Molecular Weight

30-40 kDa

Species

Mouse