Recombinant Mouse PCSK9/NARC1 Protein (His Tag)

Specifications

Catalog number

PKSM041128-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development.

Abbreviation

PCSK9; NARC1

Synonyms

FH3; HCHOLA3; NARC-1; Narc1; Neural Apoptosis-Regulated Convertase 1; PC9; Pcsk9; Proprotein Convertase 9; Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9

UniProt

Q80W65

Accession Number

Q80W65

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln35-Gln155&Ser156-Gln694

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

14&58.2 kDa

Observed Molecular Weight

19&60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.

Species

Mouse