Recombinant Mouse LIMP-2/LIMPII Protein (Fc Tag)

Specifications

Catalog number

PKSM041135-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lysosome membrane protein II (LIMPII), also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD) . Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF) . Alternatively spliced transcript variants encoding different isoforms have been found for this gene. In addition, LIMPII also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation.

Abbreviation

LIMP-2; LIMPII

Synonyms

85 kDa lysosomal membrane sialoglycoprotein; LGP85; LIMP II; Lysosome membrane protein 2; Lysosome membrane protein II; Scarb2; Scavenger receptor class B member 2

UniProt

O35114

Accession Number

O35114

Expression System

HEK293 Cells

Tag

C-His

Sequence

Arg27-Thr432

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

47.1 kDa

Observed Molecular Weight

65-90 kDa

Species

Mouse