Recombinant Mouse Sclerostin/SOST Protein (His Tag)

Specifications

Catalog number

PKSM041137-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.

Abbreviation

Sclerostin; SOST

Synonyms

Sclerostin; Sost

UniProt

Q99P68

Accession Number

Q99P68

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln24-Tyr211

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

21.9 kDa

Observed Molecular Weight

32 kDa

Species

Mouse