Recombinant Mouse SerpinD1/HCF2 Protein (His Tag)

Specifications

Catalog number

PKSM041140-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SerpinD1, also known as heparin cofactor II (HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.

Abbreviation

SerpinD1; HCF2

Synonyms

HC-II; Heparin cofactor 2; Heparin cofactor II; Protease inhibitor leuserpin-2; Serpin D1

UniProt

P49182

Accession Number

P49182

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu24-Ser478

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

53.1 kDa

Observed Molecular Weight

70-90 kDa

Species

Mouse