Recombinant Mouse Serpin G1/C1IN Protein (His Tag)

Specifications

Catalog number

PKSM041143-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement system to prevent spontaneous activation. SERPIN G1 may play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. SERPIN G1 prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. SERPIN G1 is a very efficient physiological inhibitor of FXIIa, plasma kallikrein and fXIa, and could inhibit chymotrypsin and kallikrein. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases in the C1 complex of classical pathway of complement. Activation of the C1 complex is under control of the C1-inhibitor.

Abbreviation

Serpin G1; C1IN

Synonyms

C1 Inh; C1 esterase inhibitor; C1-inhibiting factor; C1nh; Plasma protease C1 inhibitor; SERPIN G1; Serping1

UniProt

P97290

Accession Number

P97290

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala20-Gly504

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

54.6 kDa

Observed Molecular Weight

90 kDa

Species

Mouse