Recombinant Mouse CD150/SLAM Protein (His Tag)

Specifications

Catalog number

PKSM041149-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains, transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM) . SLAM is thought to play an important role in adhesion between T cells and APCs and has been shown to act as a coreceptor in TCR-dependent responses. SLAM, together with CD46, is one of the two receptors for measles virus. SLAM is a cell surface receptor that, like the B cell receptor, CD40, and CD95, can transmit positive or negative signals. SLAM can associate with the SH2-containing inositol phosphatase (SHIP), the SH2-containing protein tyrosine phosphatase (SHP-2), and the adaptor protein SH2 domain protein 1A. It’s upregulated on activated B cells and CD4+ and CD8+ T cells, but downregulated on Th2 polarized cells. Also, it can Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells

Abbreviation

CD150; SLAM

Synonyms

CD150; CD150 antigen; SLAM; SLAM family member 1; SLAMF1; signaling lymphocytic activation molecule

UniProt

Q9QUM4

Accession Number

Q9QUM4

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr25-Pro242

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.2 kDa

Observed Molecular Weight

40-60 kDa

Species

Mouse