Recombinant Mouse TSLP Receptor/CRLF2 Protein (His Tag)

Specifications

Catalog number

PKSM041157-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Rα chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.

Abbreviation

TSLP Receptor; CRLF2

Synonyms

CRL2; CRL2 cytokine receptor; CRLF2; Cytokine receptor-like 2; IL-XR; ILXR; P2RY8/CRLF2 fusion; TSLP receptor; TSLPR; Thymic stromal lymphopoietin protein receptor; Thymic stromal-derived lymphopoietin receptor; cytokine receptor-like factor 2

UniProt

Q8CII9

Accession Number

AAH23788.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala20-Leu233

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

23.7 kDa

Observed Molecular Weight

35-40 kDa

Species

Mouse