Recombinant Mouse TIMP2/TIMP-2 Protein (His Tag)

Specifications

Catalog number

PKSM041160-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse Metalloproteinase inhibitor 2 (TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs) . There are four mammalian members of the family; TIMP-1, TIMP-2, TIMP-3, and TIMP-4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.

Abbreviation

TIMP2; TIMP-2

Synonyms

CSC-21Ktissue inhibitor of metalloproteinase 2; TIMP metalloproteinase inhibitor 2; TIMP-2; Tissue inhibitor of metalloproteinase 2.; metalloproteinase inhibitor 2

UniProt

P25785

Accession Number

P25785

Expression System

HEK293 Cells

Tag

C-His

Sequence

Cys27-Pro220

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

22.5 kDa

Observed Molecular Weight

21 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Mouse