Recombinant Mouse TL1A Protein

Specifications

Catalog number

PKSM041163-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.

Abbreviation

TL1A

Synonyms

TL1; TNF Ligand-Related Molecule 1; TNFSF15; Tumor Necrosis Factor Ligand Superfamily Member 15; VEGI; Vascular Endothelial Cell Growth Inhibitor

UniProt

Q5UBV8

Accession Number

AAV33431.1

Expression System

E.coli

Tag

None

Sequence

Ile76-Leu252

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.0 kDa

Observed Molecular Weight

19 kDa

Species

Mouse