Recombinant Mouse CD30/TNFRSF8 Protein (His Tag)

Specifications

Catalog number

PKSM041164-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) . CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate. Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling.

Abbreviation

CD30; TNFRSF8

Synonyms

CD30; CD30L receptor; Lymphocyte activation antigen CD30; Tnfrsf8 ; Tumor necrosis factor receptor superfamily member 8

UniProt

Q60846

Accession Number

Q60846

Expression System

HEK293 Cells

Tag

C-His

Sequence

Phe19-Thr281

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

28.4 kDa

Observed Molecular Weight

55-65 kDa

Species

Mouse