Recombinant Mouse Cathepsin S/CTSS Protein (His Tag)

Specifications

Catalog number

PKSM041202-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease (AD) and Down Syndrome (DS) .

Abbreviation

Cathepsin S; CTSS

Synonyms

CTSS; Cathepsin S

UniProt

O70370

Accession Number

O70370

Expression System

HEK293 Cells

Tag

C-His

Sequence

Val18-Ile340

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.5 kDa

Observed Molecular Weight

37&28-32&14 kDa

Species

Mouse