Recombinant Mouse SLAMF5/CD84 Protein (His Tag)

Specifications

Catalog number

PKSM041204-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hematopoietic cell types, including monocytes, macrophages, dendritic cells, B lymphocytes, and platelets. Activation of cell surface CD84 initiates a signaling cascade involving its intra-cytoplasmic tyrosine residues that results in Bcl-2 upregulation, which in turn enhances cell survival. Either immunoneutralization or blockade of CD84 with a CD84 extracellular domain protein fragment induces cell death in vitro and in vivo.

Abbreviation

SLAMF5; CD84

Synonyms

CD84; CD84 antigen; CD84 molecule; Cd84; Leukocyte differentiation antigen CD84; Ly-9B; SLAM family member 5; SLAMF5; Signaling lymphocytic activation molecule 5

UniProt

Q18PI6

Accession Number

AAD02273.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Lys22-Pro223

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

23.8 kDa

Observed Molecular Weight

35-40 kDa

Species

Mouse