Recombinant Mouse CD5 Protein (aa 24-370, His Tag)

Specifications

Catalog number

PKSM041222-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD5 is a transmembrane glycoprotein of the conserved scavenger receptor cysteine-rich (SRCR) superfamily and expressed on thymocytes, peripheral T cells and a subset of B cells (B1-a) . Moreover, CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. The long cytoplasmic tail of CD5 has no intrinsic enzymatic activity, but contains four tyrosine phosphorylation sites, including an immunoreceptor tyrosine-based (ITAM) -like motif (pseudo-ITAM) and an immunoreceptor tyrosine-based inhibitory (ITIM) -like motif (pseudo-ITIM), as well as multiple potential serine and threonine phosphorylation sites. It physically associates with the T cell antigen receptor (TCR) and B cell antigen receptor (BCR), where it negatively modulates the activation and differentiation signals transduced by these receptors. CD5 also plays an important role in protection from activation-induced cell death and in the recognition of pathogen associated molecular patterns (PAMPS) present on fungal surfaces.

Abbreviation

CD5

Synonyms

CD5; CD5 antigen; CD5 antigen (p56-62) ; CD5 molecule; LEU1T-cell surface glycoprotein CD5; Leu-1; Ly-1; Lymphocyte antigen T1; T-cell surface glycoprotein CD5; T1

UniProt

P13379

Accession Number

P13379

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln24-Asn370

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.9 kDa

Observed Molecular Weight

42-58 kDa

Species

Mouse