Recombinant Mouse CNDP2/CPGL/PEPA Protein (His Tag)

Specifications

Catalog number

PKSM041231-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse cytosolic non-specific dipeptidase (CNDP2) is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 has 2 Isoform: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level) . Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 hydrolyzes a variety of dipeptides including L-carnosine and has a strong preference for Cys-Gly. It is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis. It may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.

Abbreviation

CNDP2; CPGL; PEPA

Synonyms

CNDP dipeptidase 2; CNDP2; Cytosolic non-specific dipeptidase; Dip-2; Glutamate carboxypeptidase-like protein 1; Pep-1; Pep1

Accession Number

Q9D1A2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Asn475

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

53.8 kDa

Observed Molecular Weight

56-60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.

Species

Mouse