Recombinant Mouse ALK-1/ACVRL1 Protein (Fc Tag)

Specifications

Catalog number

PKSM041235-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.

Abbreviation

ALK-1; ACVRL1

Synonyms

ACVRL1; ALK-1; Activin receptor-like kinase 1; SKR3; Serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; TSR-I; activin A receptor; activin A receptor type II-like 1

UniProt

Q61288

Accession Number

Q61288

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Asp23-Pro119

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.1 kDa

Observed Molecular Weight

55-60 kDa

Species

Mouse