Recombinant Mouse SLAMF7/CD319 Protein (His Tag)

Specifications

Catalog number

PKSM041236-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SLAM family member 7/CRACC is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mature mouse CRACC consists of a 202 amino acid extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain, a 21 aa transmembrane segment, and an 88 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs. CRACC is expressed on the surface of NK cells, CD8+ T cells, activated B cells, and mature dendritic cells. It interacts homophilically to induce NK, CTL, and B cell activation.

Abbreviation

SLAMF7; CD319

Synonyms

19A;19A24;4930560D03Rik; CD319; CRACC; CRACCl; CS1; Leukocyte cell-surface antigen; Novel Ly9; SLAM family member 7; Slamf7

Accession Number

Q8BHK6

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser23-Gly224

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.1 kDa

Observed Molecular Weight

30-42 kDa

Species

Mouse