Recombinant Mouse APCS/SAP Protein (His Tag)

Specifications

Catalog number

PKSM041239-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Pentraxin 2 (PTX2), also known as Serum amyloid P (SAP), is a highly conserved, naturally circulating plasma protein and a soluble pattern recognition receptor of the innate immune system. The unique binding activities indicated that it may play an important role in the removal of damaged tissue. PTX2 belongs to the pentraxin family, is universally present in amyloid deposits. Mouse with targeted deletion of the PTX2 gene shows retarded and reduced induction of experimental reactive systemic (AA type) amyloidosis confirmed that it does indeed contribute to pathogenesis of amyloidosis and is a valid therapeutic target. In recent discovery, PTX2 can be used as a powerful antifibrotic agent to regulate certain monocyte differentiation states.

Abbreviation

APCS; SAP

Synonyms

9.5S alpha-1-glycoprotein; APCS; MGC88159; PTX2; PTX2serum amyloid P-component; SAP; SAP pentaxin-related; Serum amyloid P

Accession Number

P12246

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln21-Asp224

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

24.9 kDa

Observed Molecular Weight

28-32 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 50mM Imidazole, 5% Trehalose, 20% Glycerol, pH8.0.

Species

Mouse