Recombinant Mouse CD28/TP44 Protein (Fc & His Tag)

Specifications

Catalog number

PKSM041241-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs) . The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

Abbreviation

CD28; TP44

Synonyms

CD28; CH29-189K17.3; T-cell-specific surface glycoprotein CD28

Accession Number

P31041

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Asn20-Lys149

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

43.0 kDa

Observed Molecular Weight

60 kDa

Species

Mouse