Recombinant Mouse CD5L Protein (His Tag)

Specifications

Catalog number

PKSM041246-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD5L, also known as CD5 antigen-like, is secreted protein which mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. It is able to inhibit lipid droplet size in adipocytes. CD5L acts as a key regulator of metabolic switch in T-helper Th17 cells. It is Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies. It also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis. It is involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy.

Abbreviation

CD5L

Synonyms

AAC-11; AI047839; Aim; Api6; Apoptosis inhibitor expressed by macrophages; Apoptosis inhibitory 6; CD5 antigen-like; CT-2; CT2; Cd5l; Pdp; SP-alpha; Sp-alpha

UniProt

Q9QWK4

Accession Number

Q9QWK4

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu22-VaL352

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.4 kDa

Observed Molecular Weight

52 kDa

Species

Mouse