Recombinant Mouse BMPRIA/ALK-3 Protein (Fc & His Tag)

Specifications

Catalog number

PKSM041249-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ALK-3 is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. The BMP receptors consists of the type I receptors BMPR1A and BMPR1B and the type I I receptor BMPR2. Seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors function in TGF-beta superfamily signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-3 contains a GS domain and a protein kinase domain. ALK-3 is widely expressed. Defects in BMPR1A gene are a cause of a significant proportion of cases of Juvenile polyposis syndrome (JPS) .

Abbreviation

BMPRIA; ALK-3

Synonyms

ALK-3; Activin receptor-like kinase 3; Acvrlk3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPR-IA; Bmpr; Bone morphogenetic protein receptor type-1A; CD292; SKR5; Serine/threonine-protein kinase receptor R5

UniProt

P36895

Accession Number

P36895

Expression System

HEK293 Cells

Tag

C-Fc-His

Sequence

Gln24-Arg152

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42.2 kDa

Observed Molecular Weight

55-60&120 kDa

Species

Mouse