Recombinant Mouse PRLR/Prolactin Receptor Protein (Fc Tag)

Specifications

Catalog number

PKSM041287-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human breast tissue, and in most breast cancer cells. PRLR contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region required for the activation of the Jak2–Stat5 signal transduction pathway by Prl which is essential for transcriptional activation of all known prolactin regulated genes. PRLRs have also been observed in ovarian follicular cells of mice, pigs, sheep, deer, and humans, as well as in luteal tissue in cow and horse ovaries. Furthermore, PRLR knockout mice exhibit failure of embryonic implantation, reduced number of mature oocytes, and low fertilization rates. Knockout females also display a reduced number of primary follicles.

Abbreviation

PRLR; Prolactin Receptor

Synonyms

PRL-R; PRLR; Prlr; Prolactin R; Prolactin receptor

UniProt

Q08501

Accession Number

Q08501

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln20-Asp229

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

51.7 kDa

Observed Molecular Weight

62-88 kDa

Species

Mouse