Recombinant Mouse PDGF-BB Protein (His Tag)

Specifications

Catalog number

PKSM041293-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor, it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. It is required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. PDGFB also plays an important role in wound healing.

Abbreviation

PDGF-BB

Synonyms

Becaplermin; PDGF Subunit B; PDGF-2; PDGF2; PDGFB; Platelet-Derived Growth Factor B Chain; Platelet-Derived Growth Factor Beta Polypeptide; Platelet-Derived Growth Factor Subunit B; Proto-Oncogene c-Sis; SIS

UniProt

P31240

Accession Number

AAH53430.1

Expression System

E.coli

Tag

C-His

Sequence

Ser82-Thr190

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

13.4 kDa

Observed Molecular Weight

15 kDa

Species

Mouse