Recombinant Mouse CD36/SCARB3 Protein (Fc Tag)

Specifications

Catalog number

PKSM041294-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Dermatopontin is a widely expressed noncollagenous protein component of the extracellular matrix. It is a 22 kDa molecule that is tyrosine sulfated but not glycosylated. Dermatopontin is down regulated in fibrotic growths such as leiomyoma and scar tissue, inhibits cell proliferation, accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation, Dermatopontin deficient mice exhibit altered collagen matrix deposition and organization. Dermatopontin seems to mediate adhesion by cell surface integrin binding, may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment, and enhances TGFB1 activity (By similarity) . Dermatopontin promotes bone mineralization under the control of the vitamin D receptor and inhibits BMP-2 effects on osteoblast precursors.

Abbreviation

CD36; SCARB3

Synonyms

CD36; GPIIIB; GPIV; Glycoprotein IIIb; PAS IV; PAS-4; Platelet glycoprotein IV

UniProt

Q08857

Accession Number

Q08857

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gly30-Lys439

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

73.5 kDa

Observed Molecular Weight

100-130 kDa

Species

Mouse