Recombinant Mouse PLA2G1B/PLA2 Protein (His Tag)

Specifications

Catalog number

PKSM041296-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mouse phospholipase A2 is a secreted protein which belongs to the phospholipase A2 family. Phospholipase A2/PLA2G1B catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. PLA2G1B has been thought to play major role in digestion of glycerophospholipids in nutrients, given its abundance in digestive organs. Since its expression has been observed in non-digestive organs including the lung, spleen, kidney, ovary, retina, brain, and neurons, its function may not limited to digestive role. PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.

Abbreviation

PLA2G1B; PLA2

Synonyms

Group IB phospholipase A2; PLA2-Ib; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; Pla2; Pla2g1b

UniProt

Q9Z0Y2

Accession Number

Q9Z0Y2

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala16-Cys146

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

15.6 kDa

Observed Molecular Weight

15 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.0.

Citation 01

https://www.sciencedirect.com/science/article/pii/S1931312817303943

Species

Mouse