Recombinant Mouse MARCO Protein (His Tag)

Specifications

Catalog number

PKSM041305-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

MARCO (macrophage receptor with collagenous structure) is an 80 kDa type II transmembrane glycoprotein that belongs to the class Ascavenger receptor family. Mouse MARCO consists of a 48 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 449 aa extracellulardomain (ECD) that includes a stalk region, a collagenlikeregion, and one SRCR domain. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. MARCO binds LPS, lipoteichoic acid, and otherdeterminants on Gram positive and Gram negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2.

Abbreviation

MARCO

Synonyms

Ly112; Macrophage receptor MARCO; Macrophage receptor with collagenous structure; Marco; Scara2

UniProt

Q60754

Accession Number

Q60754

Expression System

HEK293 Cells

Tag

N-His

Sequence

Gln70-Ser518

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

46.2 kDa

Observed Molecular Weight

55-65 kDa

Species

Mouse