Recombinant Mouse MGL2/CD301b Protein (His Tag)

Specifications

Catalog number

PKSM041306-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Macrophage galactose N-acetyl-galactosamine-specific lectin 2 (Mgl2), also known as CD301b, is a 38 kDa member that belongs to the C-type lectin family. Two MGL proteins are encoded by separate genes in the mouse, but share 91% amino acid (aa) identity in the extracellular domain (ECD) . Only one MGL occurs in human and rat and this MGL is structurally more similar to mouse MGL1 than MGL2. However, human MGL and mouse MGL2 both bind specifically to terminal GalNAc residues, in contrast with mouse MGL1 which binds Lewis X. GalNAc recognition is likely to be important in dendritic cell-mediated tolerance to self-gangliosides as well as recognition of tumor antigens and parasite glycoproteins.

Abbreviation

MGL2; CD301b

Synonyms

CD301b; Macrophage Galactose-type C-lectin 2; Macrophage galactose N-acetyl-galactosamine-specific lectin 2; Mgl2

UniProt

Q8JZN1

Accession Number

Q8JZN1

Expression System

HEK293 Cells

Tag

N-His

Sequence

Ser72-Pro332

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

30.9 kDa

Observed Molecular Weight

30-40 kDa

Species

Mouse