Recombinant Mouse LRIG1 Protein (His Tag)

Specifications

Catalog number

PKSM041310-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit the growth of different types of malignancies. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a kind of transmembrane glycoprotein, which is induced by epidermal growth factor (EGF) and develops inhibitory negative feedback by specific binding with epidermal growth factor receptor (EGFR) . LRIG1 expression is broadly decreased in human cancer and breast cancer and low expression of LRIG1 has been linked to decreased relapse-free survival.

Abbreviation

LRIG1

Synonyms

LIG-1; Leucine-rich repeats and immunoglobulin-like domains protein 1; Lrig1

UniProt

P70193

Accession Number

P70193

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala35-Thr794

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

84.5 kDa

Observed Molecular Weight

94 kDa

Species

Mouse