Recombinant Mouse Lumican/LUM Protein (His Tag)

Specifications

Catalog number

PKSM041313-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Keratan sulfate proteoglycan lumican, mostly known as lumican, belongs to the SLRP class II subfamily and the small leucine-rich proteoglycan (SLRP) family. Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production. Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage. The abnormal connective tissue phenotype seen in the Lumican null mice shows the importance of the role of Lumican in collagen fibrillogenesis. In addition to the control of collagen fibril assembly, Lumican has been shown to play a role in the regulation of cell proliferation, migration, and adhesion.

Abbreviation

Lumican; LUM

Synonyms

KSPG lumican; Keratan sulfate proteoglycan lumican; LDC; Lumican

UniProt

P51885

Accession Number

P51885

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln19-Asn338

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

37.4 kDa

Observed Molecular Weight

40-60 kDa

Species

Mouse