Recombinant Mouse Kallikrein 1/KLK1 Protein (His Tag)

Specifications

Catalog number

PKSM041314-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Kallikreins belongs to the family of trypsin-like serine proteases, many of which are associated with a variety of cancers. Kallikrein 1 (KLK1) is also known as tissue kallikrein and urinary kallikrein. KLK1 is synthesized as a 261 amino acid (aa) protein that contains a 18 aa signal peptide and a 241 aa proprotein. An important physiological function of KLK1 cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Kinins regulate vasodilation, blood pressure reduction, smooth muscle relaxation and contraction, pain induction and inflammation.

Abbreviation

Kallikrein 1; KLK1

Synonyms

Glandular kallikrein K1; KAL-B; Renal kallikrein; Tissue kallikrein-6; mGK-6

UniProt

P15947

Accession Number

P15947

Expression System

HEK293 Cells

Tag

C-His

Sequence

Pro19-Asp261

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

27.9 kDa

Observed Molecular Weight

34-38 kDa

Species

Mouse