Recombinant Mouse SerpinE2/SERPINE2 Protein (His Tag)

Specifications

Catalog number

PKSM041335-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Serpin E2 is a member of the Serpin superfamily of the serine protease inhibitors. Serpin E2 is apotent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform humanembryonic kidney cells into neuronlikecells. Its over-expressionin mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressedin the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronicpancreatitis tissue samples. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from theonset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.

Abbreviation

SerpinE2; SERPINE2

Synonyms

GDN; Glia-derived nexin; PI-7; PN-1; Peptidase inhibitor 7; Pi7; Pn1; Protease nexin 1; Protease nexin I; Serine protease-inhibitor 4; Serpin E2; Spi4

UniProt

Q07235

Accession Number

Q07235

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser20-Pro397

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

43.2 kDa

Observed Molecular Weight

50-55 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Sodium Acetate, 150 mM NaCl, 5% Trehalose, 5% Mannitol, 0.02% Tween 80, 1mM EDTA, pH 4.0.

Species

Mouse