Recombinant Mouse FOLR1 Protein (aa 25-232, His Tag)

Specifications

Catalog number

PKSM041337-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Folate Receptor alpha belongs to the folate receptor family and it is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates.Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 can be detected in kidney proximal tubules. It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.

Abbreviation

FOLR1

Synonyms

Adult folate-binding protein; FBP; FBP1; FOLR; FOLR1; FR-alpha; Folate receptor; Folate receptor 1; Folbp-1; Folbp1; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18; adult; folate binding protein; folate receptor 1 (adult) ; folate receptor alpha

UniProt

P35846

Accession Number

P35846

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr25-Ser232

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

25.3 kDa

Observed Molecular Weight

33-37 kDa

Species

Mouse