Recombinant Mouse EpCAM/TROP-1 Protein (Fc Tag)

Specifications

Catalog number

PKSM041339-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Epithelial Cellular Adhesion Molecule (Ep-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the EPCAM family. Its’ monomer subunit structure interacts with phosphorylated CLDN7. Ep-CAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. It also up-regulates the expression of FABP5, MYC and cyclins A and E. The post-translational modification glycosylation at Asn-198 is crucial for protein stability.

Abbreviation

EpCAM; TROP-1

Synonyms

CD326; E; EGP; EGP-2; Epithelial cell adhesion molecule; Neurotrophic tyrosine kinase receptor-related 1; ROR1; TROP1; Tumor-associated calcium signal transducer 1; receptor tyrosine kinase-like orphan receptor 1; tyrosine-protein kinase transmembrane receptor ROR1

UniProt

Q99JW5

Accession Number

Q99JW5

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln24-Thr266

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

54.8 kDa

Observed Molecular Weight

60-80 kDa

Species

Mouse