Recombinant Mouse EDA2R/TNFRSF27 Protein (Fc Tag)

Specifications

Catalog number

PKSM041342-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA-A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down-regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA-A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.

Abbreviation

EDA2R; TNFRSF27

Synonyms

EDA-A2 receptor; EDA-A2R; EDAA2R; EDAR2; Ectodysplasin A2 receptor; TNFRSF27; Tumor necrosis factor receptor superfamily member 27; Tumor necrosis factor receptor superfamily member XEDAR; X-linked ectodysplasin-A2 receptor; XEDAR

UniProt

Q8BX35

Accession Number

BAC28879

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Met1-Thr138

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

42.5 kDa

Observed Molecular Weight

50-60 kDa

Species

Mouse