Recombinant Mouse SerpinA1/A1AT Protein (His Tag)

Specifications

Catalog number

PKSM041362-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Alpha-1-antitrypsin 1-3 (SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.

Abbreviation

SerpinA1; A1AT

Synonyms

Alpha-1 protease inhibitor 3; Alpha-1 protease inhibitor 6; Alpha-1-antitrypsin 1-3; Alpha-1-antitrypsin 1-6; Dom3; Dom6; Serine protease inhibitor 1-3; Serine protease inhibitor 1-6; Serine protease inhibitor A1c; Serpin A1c; Serpina1c; Spi1-3; Spi1-6

UniProt

P07758

Accession Number

AAH11040.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu25-Lys413

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

44.3 kDa

Observed Molecular Weight

50-60 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Species

Mouse