Recombinant Mouse Alpha-1-antitrypsin 1-1/Serpin A1e (C-6His)

Specifications

Catalog number

PKSM041392-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Alpha-1-antitrypsin 1-5 (SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.

Abbreviation

Serpin A1e

Synonyms

Alpha-1 protease inhibitor 5; Alpha-1-antitrypsin 1-5; Dom5; Serine protease inhibitor 1-5; Serine protease inhibitor A1e; Serpin A1e; Serpina1e; Spi1-5

UniProt

Q00898

Accession Number

Q00898

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu25-Lys413

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

44.5 kDa

Observed Molecular Weight

47-68 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.

Species

Mouse