Recombinant Mouse Interleukin-36 gamma/IL-36 gamma/IL-1F9

Specifications

Catalog number

PKSM041397-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta) . IL-36γ plays an important role in communicating the cell death to surrounding cells.

Abbreviation

IL-36 gamma; IL-1F9

Synonyms

Il1f; IL-1-related protein; Interleukin-1 homolog; IL-1F; IL-1H; IL-1RP; IL-1 epsilon; IL-1F9; IL-1H1; IL-1-related protein 2; IL-1RP2; Interleukin-1 homolog 1; Interleukin-36 gamma; Il1f9; Il36g; IL-17E

UniProt

Q8R460

Accession Number

Q8R460

Expression System

E.coli

Tag

None

Sequence

Gly13-Ser164

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

17.3 kDa

Observed Molecular Weight

17 kDa

Species

Mouse