Recombinant Mouse TPBG/5T4 (C-6His)

Specifications

Catalog number

PKSM041401-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Abbreviation

TPBG;5T4

Synonyms

5T4 Protein;5T4AG Protein; Human; M6P1 Protein; WAIF1 Protein

UniProt

Q9Z0L0

Accession Number

Q9Z0L0

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser32-Ser361

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

36.6 kDa

Observed Molecular Weight

50-70 kDa

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Species

Mouse