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Product details

Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)

Catalog number PKSM041409-01

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Size / count 10 µg

Specifications

Catalog number
PKSM041409-01
Size / count
10 µg
Dry ice
No
Hazardous
No
Discontinued
No
Background
NKG2-D type II integral membrane protein (NKG2D) is a type II transmembrane glycoprotein which belongs to the CD94/NKG2 family. NKG2D is expressed on natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. As an activating and costimulatory receptor, it involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. It stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. NKG2D participates in NK cell-mediated bone marrow graft rejection and survival of NK cells. It Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Abbreviation
NKG2D; CD314
Synonyms
CD314; CD314 antigen; KLR; KLRK1; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D; killer cell lectin-like receptor subfamily K; member 1
UniProt
O54709
Accession Number
O54709
Expression System
HEK293 Cells
Tag
N-His
Sequence
Phe94-Val232
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
16.7 kDa
Observed Molecular Weight
20-30 kDa
Species
Mouse

Frequently Asked Questions

What is the catalog number for Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)?

The catalog number for Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) is PKSM041409.

What sizes are available for Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)?

Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) is available in the following size(s): 10 µg, 50 µg.

How many pack sizes does Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) come in?

Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) is available in 2 different pack sizes.

Is Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) in stock?

Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)?

Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) is manufactured by Elabscience.

What is the estimated delivery time for Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)?

Estimated delivery time for Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His)?

The safety data sheet for Recombinant Mouse NKG2-D type II Integral Membrane Protein/NKG2D/CD314 (N-6His) is available here: https://789.bio/eb/r9CWnT.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

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