Recombinant Mouse Transforming Growth Factor-Beta Receptor Type II/TGFBR2 (C-Fc)

Specifications

Catalog number

PKSM041417-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinity cell surface receptors: TGF-β receptor type I (TGF-β-RI), TGF-β receptor type II (TGF-β-RII), and TGF-ββ receptor type III (TGF-β-RIII) . TGF-β RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-β) receptor subfamily. TGF-β RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

Abbreviation

TGFBR2

Synonyms

TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; TGFR-2; TbetaR-II; Tgfbr2; Transforming growth factor-beta receptor type II

UniProt

Q62312

Accession Number

Q62312

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ile24-Asp184

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

45 kDa

Observed Molecular Weight

60-75 kDa

Species

Mouse