Recombinant Mouse TGFBR3 (C-6His)

Specifications

Catalog number

PKSM041420-01

Size / count

10 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transforming growth factor beta receptor III (TGF-beta RIII; also betaglycan) is a ubiquitously expressed, 280 kDa type I transmembrane proteoglycan member of the TGF-beta superfamily of proteins. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. TGF-beta RIII can enhance or inhibit cell signaling. TGF-beta RIII has been shown to play an essential role in the formation of the atrioventricular cushion and coronary vessels during development of the heart. TGF beta RIII also plays a role in many cancers. Increased expression of TGF beta RIII is found in higher grade lymphomas, and reduced expression of TGF beta RIII is found with advanced stage neuroblastomas and ovarian carcinomas. Low TGF-beta RIII expression also correlates with higher grade among a cohort of breast cancers. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.

Abbreviation

TGFBR3

Synonyms

InBGCAN; TBRIII; TGF-bRIII; TGF-beta RIII; TGF-beta receptor type 3; TGF-beta receptor type III; TGFBR3; TGFR-3; TGFbetaRIII; Transforming growth factor beta receptor III

UniProt

A0A0R4J097

Accession Number

A0A0R4J097

Expression System

HEK293 Cells

Tag

C-His

Sequence

Glu23-Thr785

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

85.9 kDa

Observed Molecular Weight

110-125 kDa

Species

Mouse